Enzyme Supply

Iosynth offers scalable biocatalytic solutions and is one of the main suppliers of enzymes to the Indian Pharmaceutical, Fine Chemical, and Cosmetic Industry. Our warehouse and logistic setup allows customers across India to streamline their supply chain operation for their enzyme needs. Almost all of our enzymes are available for industrial processes up to ton scale. Easy, accessible biocatalysis.


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Iosynth offers a broad range of enzymes used for biocatalysis, antibiotics production, specialty enzyme applications. Our enzyme portfolio provides a continually expanding toolbox with innovative biocatalysts


Enzymes for Biocatalysis
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The “workhorse” for industrial biocatalysis applications are hydrolases, mainly lipases and proteases. These enzymes are well researched, very cost-effective to apply, and available at commercial scale. Through our partnership with Novozymes, we supply well-known lipases such Lipozyme CALB, Novozym 435, Lipozyme TL, Novoyzm 40086, Savinase 12T, Alcalase 2.5L and many more.


Other enzyme classes that we supply on a more frequent basis:
ENZYMES
Hydrolase (Lipase, Protease, Esterase, etc)
Ketoreductase (KRED) / Alcohol dehydrogenase (ADH)
Nitrilase
Nitrile Hydratase
Transaminase
Amidase
Imine Reductase
P450 monooxygenase
Ene Reductase
Hydantoinase
Horseradish Peroxidase (HRP)
Pig Liver Esterase
Baeyer-Villiger monooxygenases

If your required enzyme is not listed here, please advise us of your requirements. There is a very high chance that we will be able to supply you with this enzyme as well.


Co-factors and co-factor recycling enzymes (regeneration enzymes)

Some enzyme reactions require co-factors (or coenzymes) for the enzyme to react.

COENZYMES
NAD
NADP
NADH
NADPH
PLP
NMN
REGENERATION ENZYMES
Glucose dehydrogenase (GDH)
Formate dehydrogenase (FDH)
NAD(P)H Oxidase
Lactate dehydrogenases

If your required enzyme is not listed here, please advise us of your requirements. There is a very high chance that we will be able to supply you with this enzyme as well.


Screening kits
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We have a broad range of screening kits for many enzymes available. Please contact us for more details


Enzymes for Antibiotics and Beta-Lactam production
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The use of enzymes in the production of antibiotics and beta-lactams is probably one of the most established applications of enzymes in the pharmaceutical industry. The traditional PenG enzyme is still widely used, but there is also a lot of innovation coming to this segment: Enzymes for new pathways and new classes of antibiotics, as well as innovation in the formulation which allow customers to get more cycles out of their enzymes. Our enzymes in this segment have a high substrate selectivity and a high specific activity. For customers this means smooth operation with excellent cost-effectiveness.

Our enzymes address a very broad portfolio of antibiotics and intermediates

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Beta-Lactamase

Sterility Testing

US Pha

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Iosynth offers best-in-class beta lactamase for antibiotic sterility testing and environmental monitoring.

Sterility Testing

US Pharmacopeia (USP) Chapter 71 and EP Section 2.6 describe sterility testing of bulk antibiotics, which should be shown to be free from microbial contamination. The testing requires the removal of significant amounts of active antibiotic from solution by combined filtration and the use of penicillinase or β-Lactamase, The resulting solution is tested for the (lack of) growth of microbes.


Our beta-lactamase has significantly higher activity against clinically important beta-lactams, it inactivates clinical relevant cephalosporins better than any other product available on the market.



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Environmental Monitoring Plates

Contact plates, settle plates and air monitoring systems for testing of aseptic conditions in antibiotic manufacturing facilities need to be manufactured with agar medium for neutralization of antibiotic. This is achieved by the addition of Penicillinase or β-Lactamase to the medium. Through this, any antibiotic residues are hydrolyzed and microbial contamination can be detected.



Our Beta-Lactam agar plates are available as contact and settle plates for high performance monitoring of your isolators and clean rooms during beta lactam manufacture.


Other enzyme applications

Iosynth is best known for supplying enzymes for biocatalysis, however enzymes are also routinely used for multiple other applications, such as cell culture, biosimilars, and diagnostics, digestive aids. Iosynth has an in-depth knowledge of specialty applications in the pharma, food, cosmetics, agro-chemical and fine chemical industries. The diversity of applications is too large to fully cover here. Please contact us with your specific question or enzyme need. We will be happy to help you.